Pantelis Antonoudiou1, Eric Teboul1, Kenneth A. Amaya1, Bradly T. Stone2, Kaitlyn E. Dorst1, Jamie Maguire1
Biological Psychiatry, ISSN 0006-3223, October 2024
Accumulating evidence supports a role for altered circuit function in impaired valence processing and altered affective states as a core feature of psychiatric illnesses. We review the circuit mechanisms underlying normal valence processing and highlight evidence supporting altered function of the basolateral amygdala, valence processing, and affective states across psychiatric illnesses. The mechanisms controlling network activity that governs valence processing are reviewed in the context of potential pathophysiological mechanisms mediating circuit dysfunction and impaired valence processing in psychiatric illnesses. Finally, we review emerging data demonstrating experience-dependent, biased information routing through the basolateral amygdala promoting negative valence processing and discuss the potential relevance to impaired affective states and psychiatric illnesses.
Keywords: Affective circuits; Amygdala; Neural computation; Oscillations; Psychiatric illnesses; Valence processing
1 Department of Neuroscience, Tufts University School of Medicine
2 Charles River Analytics, Inc.
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